CHIRAL SEPARATION OF $(2S,~9S)$-DIAMINO-2,9-DIBENZYLDECA-4,6-DIYNEDIOIC ACID AND $(2R,~9R)$-DIAMINO-2,9-DIBENZYLDECA-4,6-DIYNEDIOIC ACID

The enantiomers of the chiral compound (2S, 9S)-diamino-2,9-dibenzyldeca-4,6-diynedioic acid and (2R, 9R)-diamino-2,9-dibenzyldeca-4,6-diynedioic were separated by a high-performance liquid chromatography (HPLC) method. separation α-amino acids was performed using 5µ 4.0×250 mm column, which obtained on basis sorbent with eremomycin. is silica gel (with 11 nm pore diameter surface area 300 m2/g) epoxy groups grafted them antibiotic Chiral HPLC one most common methods for separating compounds. Synthesis new pharmaceutical substances, are isomers substance, obtaining drugs based them, as well need to control presence second isomer in such drugs, impose requirements modern chromat-ographic isomers.